If you've never used EndNote desktop before, the first time you open the application from the launchpad, it will look like nothing has happened!
Don't worry, you have opened it, but without an existing library to pull up, the screen stays empty. Here are the steps for creating your first EndNote library.
After you've saved and opened your EndNote desktop library, it will pop up every time you open the EndNote application in the future.
EndNote's CWYW function is changing fonts and highlighting the references in grey.