Rachel Crouch
Assistant Professor of Pharmaceutical Sciences
Publications & Presentations
2021
- Case study 11: considerations for enzyme mapping experiments-interaction between the aldehyde oxidase inhibitor hydralazine and glutathioneCrouch RD, Beers JL, Jackson KD. Case study 11: considerations for enzyme mapping experiments-interaction between the aldehyde oxidase inhibitor hydralazine and glutathione. Methods Mol Biol. 2021;2342:809-823. doi:10.1007/978-1-0716-1554-6_30
- Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CL(pro))Han SH, Goins CM, Arya T, Shin WJ, Maw J, Hooper A, Sonawane DP, Porter MR, Bannister BE, Crouch RD, Lindsey A A, Lakatos G, Martinez SR, Alvarado J, Akers WS, Wang NS, Jung JU, Macdonald JD, Stauffer SR. Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CL(pro)). J Med Chem. 2021;doi:10.1021/acs.jmedchem.1c00598
2019
- Interindividual variation in CYP3A activity influences lapatinib bioactivationBissada JE, Truong V, Abouda AA, Wines KJ, Crouch RD, Jackson KD. Interindividual variation in CYP3A activity influences lapatinib bioactivation. Drug Metab Dispos. 2019;47(11):1257. doi: 10.1124/dmd.119.088823
2018
- A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometryCrouch RD, Hutzler JM, Daniels JS. A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry. Xenobiotica. 2018;48(3):219-231. doi: 10.1080/00498254.2017.1296208
2017
- Species-specific involvement of aldehyde oxidase and xanthine oxidase in the metabolism of the pyrimidine-containing mGlu5-negative allosteric modulator VU0424238 (auglurant)Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW. Species-specific involvement of aldehyde oxidase and xanthine oxidase in the metabolism of the pyrimidine-containing mGlu5-negative allosteric modulator VU0424238 (auglurant). Drug Metab Dispos. 2017;45(12):1245-1259. doi: 10.1124/dmd.117.077552
2016
- Evaluating the disposition of a mixed aldehyde oxidase/cytochrome P450 substrate in rats with attenuated P450 activityCrouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS. Evaluating the disposition of a mixed aldehyde oxidase/cytochrome P450 substrate in rats with attenuated P450 activity. Drug Metab Dispos. 2016;44(8):1296-1303. doi: 10.1124/dmd.115.068338