Sarah Graff
Assistant Professor of Pharmacy
Research Interests
- changes in pancreatic ion channel expression during exercise and how that, in turn, regulates glucose homeostasis.
Publications & Presentations
2023
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Karolina E. Zaborska, Chloe E. Ibsen, Regan Butterworth, and David A. Jacobson. TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Submitted to Cell Reports.
2021
Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Matthew A. Brown, David A. Jacobson, Emma L. Duncan. A novel mutation in KCNK16 causing a gain-of-function in the TALK-1 potassium channel: a new cause of maturity-onset diabetes of the young. JCI Insight. 2021; PubMed PMID: 34032641
2020
Karolina E Zaborska, Prasanna K Dadi, Matthew T Dickerson, Arya Y Nakhe, Ariel S Thorson, Charles M Schaub, Sarah M Graff, Jade E Stanley, Roy S Kondapavuluru, Jerod S Denton, David A Jacobson. Lactate activation of α-cell K ATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry. Molecular Metabolism. 2020; PubMed PMID: 32736089
Matthew T Dickerson, Prasanna K Dadi, Regan B Butterworth, Arya Y Nakhe, Sarah M Graff, Karolina E Zaborska, Charles M Schaub, David A Jacobson. Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. The Journal of Physiology, 2020; PubMed PMID: 32790176
Xiaodun Yang, Sarah M. Graff, Kung-Hsien Ho, Ruiying Hu, Gregory David, David A. Jacobson, Irina Kaverina, Christopher V. E. Wright, Ken Lau, Guoqiang Gu. Co-repressor Sin3A is required for postnatal β-cell function and survival in mice. Diabetes. 2020; PubMed PMID: 32245798
2018
M. T. Dickerson, A. M. Bogart, M. K. Altman, S. C. Milian, P. K. Dadi, and D. A. Jacobson. Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation. Scientific Reports. 2018; PubMed PMID: 29348619
2017
Dickerson M, Vierra N, Milian S, Dadi P, Jacobson DA. Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells. PLOS One. 2017; 12(4). PubMed PMID: 284031695
N. C. Vierra, M. T. Dickerson, P. K. Dadi, K. L. Jordan, K.A. Kadare, M. K. Altman, S. C. Milian, and D. A. Jacobson. TALK-1 facilitation of ER calcium leak controls delta-cell calcium handling and somatostatin secretion. Molecular Metabolism. 2017; PubMed PMID: 29402588
Vierra N, Dadi P, Milian S, Dickerson M, Jordan K, Gilon P, Jacobson DA. TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis. Science Signaling. 2017; 10(497). PubMed PMID:28928238