Pharmacy Scholarship: Nate Daniels

Naguib MA, Hedges WS, McArtney GE, Leaver AG, Abdelmessih BA, Fasig ZD, Gimenez LE, Cone RD, Daniels RN. Development of allosteric modulators of MC4R for the treatment of obesity. Paper presented at: American Chemical Society Southeast Regional Meeting; October 20-23, 2019; Savanah, GA.

Amaya GM, Durandis R, Bourgeois DS, Perkins JA, Abouda AA, Wines KJ, Mohamud M, Starks SA, Daniels RN, Jackson KD. Cytochromes P450 1A2 and 3A4 catalyze the metabolic activation of sunitinib. Chem Res Toxicol. 2018;31(7):570-584. doi: 10.1021/acs.chemrestox.8b00005

Geiger HA, Wurst MG, Daniels RN. Dark classics in chemical neuroscience: Psilocybin. ACS Chem Neurosci. 2018;9(10):2438-2447. doi: 10.1021/acschemneuro.8b00186

Naguib MA, Hedges WS, McArtney GE, Leaver AG, Abdelmessih BA, Fasig ZD, Gimenez LE, Cone RD, Daniels RN. Development of allosteric modulators of MC4R for the treatment of obesity. Poster presented at: Christian Scholar’s Conference; June 6-8, 2018; Nashville, TN.

Abbott JR, Hodges TR, Daniels RN, Patel PA, Kennedy JP, Howes JE, Akan DT, Burns MC, Sai J, Sobolik T, Beesetty Y, Lee T, Rossanese OW, Phan J, Waterson AG, Fesik SW. Discovery of aminopiperidine indoles that activate the guanine nucleotide exchange factor sos1 and modulate ras signaling. J Med Chem. 2018;61(14):6002-6017. doi: 10.1021/acs.jmedchem.8b00360

Jackson KD, Amaya GM, Durandis R, Wines KJ, Abouda AA, Starks SA, Daniels RN. Metabolic activation of sunitinib: Implications for sunitinib-induced toxicities. Cancer Res. 2018;78(13 Supplement):4911. doi: 10.1158/1538-7445.AM2018-4911

Amaya GM, Durandis R, Wines KJ, Abouda AA, Starks SA, Daniels RN, Jackson KD. Metabolic activation of sunitinib: Implications for sunitinib-induced toxicities. Poster presented at: Christian Scholar’s Conference; June 6-8, 2018; Nashville, TN.

Burns MC, Sun Q, Daniels RN, Camper D, Kennedy JP, Phan J, Olejniczak ET, Lee T, Waterson AG, Rossanese OW, Fesik SW. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc Natl Acad Sci U S A. 2014;111(9):3401-3406. doi: 10.1073/pnas.1315798111

Whitfield AC, Moore BT, Daniels RN. Classics in chemical neuroscience: Levodopa. ACS Chem Neurosci. 2014;5(12):1192-1197. doi: 10.1021/cn5001759

Sheffler DJ, Nedelcovych MT, Williams R, Turner SC, Duerk BB, Robbins MR, Jadhav SB, Niswender CM, Jones CK, Conn PJ, Daniels RN, Lindsley CW. Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres. Bioorg Med Chem Lett. 2014;24(4):1062-1066. doi: 10.1016/j.bmcl.2014.01.011

Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem. 2013;56(1):15-30. doi: 10.1021/jm301448p

Daniels RN, Burns MC, Sun Q, Kim H-Y, Lee T, Waterson AG, Rossanese OW, Phan J, Fesik SW. Discovery of interfacial binders to the K-Ras/SOS complex. Poster presented at: Vanderbilt Ingram Cancer Center Retreat; May 8, 2012; Nashville, TN.

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010;5(2):245-253. doi: 10.1021/cb9002865

Miller NR, Daniels RN, Lee D, Conn PJ, Lindsley CW. Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists. Bioorg Med Chem Lett. 2010;20(7):2174-2177. doi: 10.1016/j.bmcl.2010.02.041

Daniels RN, Melancon BJ, Wang EA, et al. Progress toward the total synthesis of lucentamycin A: Total synthesis and biological evaluation of 8-epi-lucentamycin A. J Org Chem. 2009;74(22):8852-8855. doi: 10.1021/jo902115s

Daniels RN, Lindsley CW. Total synthesis and biological evaluation of 8-epi-lucentamycin A. Paper presented at: American Chemical Society Southeast Regional Meeting; October 21-24, 2009; San Juan, Puerto Rico.

Fadeyi OO, Daniels RN, DeGuire SM, Lindsley CW. Total synthesis of polemannones B and C. Tetrahedron Lett. 2009;50(25):3084-3087. doi: 10.1016/j.tetlet.2009.04.043

Kennedy JP, Williams L, Bridges TM, Daniels RN, Weaver D, Lindsley CW. Application of combinatorial chemistry science on modern drug discovery. J Comb Chem. 2008;10(3):345-354. doi: 10.1021/cc700187t

Wang EA, Daniels RN, Melancon BJ, Sulikowski GA, Lindsley CW. Efforts towards the ethylideneproline core of Lucentamycins A-D. Poster presented at: American Chemical Society Southeast Regional Meeting; November 12-15, 2008; Nashville, TN.

Daniels RN, Kim K, Lebois EP, Muchalski H, Hughes M, Lindsley CW. Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines. Tetrahedron Lett. 2008;49(2):305-310. doi: 10.1016/j.tetlet.2007.11.054

Daniels RN, Fadeyi OO, Lindsley CW. A new catalytic CU(II)/sparteine oxidant system for beta,beta-phenolic couplings of styrenyl phenols: Synthesis of carpanone and unnatural analogs. Org Lett. 2008;10(18):4097-4100. doi: 10.1021/ol801643t

Bridges TM, Brady AE, Kennedy JP, Daniels RN, Miller NR, Kim K, Breininger ML, Gentry PR, Brogan JT, Jones CK, Conn PJ, Lindsley CW. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008;18(20):5439-5442. doi: 10.1016/j.bmcl.2008.09.023

Miller NR, Daniels RN, Bridges TM, Brady AE, Conn PJ, Lindsley CW. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008;18(20):5443-5447. doi: 10.1016/j.bmcl.2008.09.032

Daniels RN, Lindsley CW. Total synthesis and biological evaluation of 8-epi-Lucentamycin A-D. Poster presented at: American Chemical Society Southeast Regional Meeting; November 12-15, 2008; Nashville, TN.

Lewis JA, Daniels RN, Lindsley CW. Total synthesis of ciliatamides A-C: Stereochemical revision and the natural product-guided synthesis of unnatural analogs. Org Lett. 2008;10(20):4545-4548. doi: 10.1021/ol801842v

Lewis JA, Daniels RN, Lindsley CW. Total synthesis of Ciliatamides A-C: Stereochemical revision and unnatural analogs. Poster presented at: American Chemical Society Southeast Regional Meeting; November 12-15, 2008; Nashville, TN.

Daniels RN, Lindsley CW. Total synthesis of Lucentamycins. Poster presented at: American Chemical Society National Meeting; April 6-10, 2008; New Orleans, LA.

Daniels RN, Lindsley CW. A new, non-SSRI mechanism of action for Prozac. Curr Top Med Chem. 2007;7(10):1039. doi: 10.2174/156802607780906807